ABSTRACT BACKGROUND AND OBJECTIVES: Since the relatively recent discovery of the endocannabinoid system (ECS) and its fundamental role in regulating other systems, the subject has aroused interest in all areas of health, including Dentistry. Among the possible uses and benefits of cannabinoids are their performance in pain and its predisposing or perpetuating factors, such as bruxism and sleep disorders. Although the literature is still scarce, the mechanisms of action and satisfactory results of cannabinoids and other cannabis derivatives in these situations already allow their safe prescription. The objective of this study was to verify the current evidence on the use of cannabis derivatives in orofacial pain (OFP), reviewing what is known, to date, about the ECS and the prospects for its use with support and criteria. CONTENTS: This research carried out a brief review of the cannabis plant history, addressing issues such as prejudice, prohibitions and interests, as well as its therapeutic use. Then, a review on ECS and its mechanisms of interest in OFP was presented. Next, the products derived from the plant and their effects, indications, contraindications, adverse effects, drug interactions, peculiarities and perspectives were discussed. CONCLUSION: The more knowledge is gained about the ECS and the therapeutic benefits of cannabis components and derivatives, the greater the conviction that a new therapeutic frontier has indeed emerged. The growing number of good outcomes, including cases of OFP, obtained through well-conducted studies, brings a mixture of satisfaction and excitement. No therapy will achieve good results if it does not start from an accurate diagnosis. Thus, it is of the utmost importance to know the ECS, the products and derivatives of the plant, the synthetic cannabinoids, their indications and effects. New studies are necessary and, at this moment, it can be said that the perspectives are very good and a new and challenging horizon is emerging.

RESUMO JUSTIFICATIVA E OBJETIVOS: Desde a descoberta relativamente recente do sistema endocanabinoide (SEC) e seu papel fundamental da regulação de outros sistemas, o assunto tem despertado interesse de todas as áreas da saúde, incluindo-se a Odontologia. Dentre as possíveis utilizações e benefícios dos canabinoides, está sua atuação na dor e seus fatores predisponentes ou perpetuadores, como o bruxismo e os distúrbios do sono. Embora a literatura seja ainda escassa, os mecanismos de ação e resultados satisfatórios dos canabinoides e demais derivados da cannabis nessas situações já permitem sua prescrição com segurança. O objetivo deste estudo foi verificar as atuais evidências sobre a utilização de derivados da cannabis nas dores orofaciais (DOFs), revisando o que se sabe, até o momento, sobre o SEC e as perspectivas de sua utilização com respaldo e critério. CONTEÚDO: Esta pesquisa realizou uma breve revisão da história da planta cannabis, abordando temas como preconceito, proibições e interesses, além de sua utilização terapêutica. Em seguida, foi apresentada uma revisão sobre o SEC e seus mecanismos de interesse na DOF. Na sequência, foram discutidos os produtos derivados da planta e seus efeitos, indicações, contraindicações, efeitos adversos, interações farmacológicas, peculiaridades e perspectivas. CONCLUSÃO: Quanto mais são adquiridos conhecimentos sobre o SEC e os benefícios terapêuticos dos componentes e derivados da cannabis, mais há um convencimento de que surgiu, de fato, uma nova fronteira terapêutica. O número crescente de bons desfechos, incluindo casos de DOF, obtidos através de estudos bem conduzidos, traz um misto de satisfação e empolgação. Nenhuma terapia obterá bons resultados se não partir de um diagnóstico preciso. Assim, é de suma importância que se conheça o SEC, os produtos e derivados da planta, os canabinoides sintéticos, suas indicações e efeitos. Novos estudos são necessários e, nesse momento, pode-se afirmar que as perspectivas são muito boas e um novo e desafiador horizonte está despontando.

RESUMO JUSTIFICATIVA E OBJETIVOS: A neuralgia trigeminal provoca intenso sofrimento e comprometimento da qualidade de vida. O diagnóstico é clínico. A termografia tem se mostrado uma ferramenta útil tanto para a confirmação quanto para o acompanhamento dessa neuralgia. A fotobiomodulação está cada vez mais bem documentada, em especial quando associada com a terapia de primeira escolha, que é a farmacoterapia. O objetivo deste estudo foi investigar a atuação do laser, associado a anticonvulsivante, em paciente com neuralgia trigeminal, considerando os seus resultados sob o ponto de vista clínico e termográfico. RELATO DO CASO: Paciente do sexo masculino, 62 anos, portador de neuralgia trigeminal idiopática, diagnosticado há 4 anos, sendo controlado com oxcarbazepina (600mg), dividida em 2 doses diárias, sendo esta dose dobrada no último ano. Nos últimos quatro meses os sintomas se agravaram com o aumento da dose do fármaco, gerando efeitos adversos não suportados pelo paciente. Foi proposta a fotobiomodulação como tratamento complementar, sendo realizada a termografia infravermelha antes e depois do tratamento. Após o protocolo de laserterapia de baixa intensidade, houve melhora significativa, demonstrada tanto pelo relato do paciente quanto observado pela termografia, mantendo-se esse resultado no controle de seis meses. O fármaco foi reduzido para 300mg/dia, o que devolveu ao paciente a qualidade de vida. CONCLUSÃO: A fotobiomodulação por laser de baixa intensidade infravermelho pode ser extremamente útil quando associada a um adequado fármaco no controle da neuralgia trigeminal idiopática, tanto no resultado imediato quanto a médio prazo.

ABSTRACT BACKGROUND AND OBJECTIVES: Trigeminal Neuralgia causes intense suffering and impaired quality of life. The diagnosis is clinical. Thermography has been proven to be a useful tool, both for confirming and monitoring this neuralgia. Photobiomodulation is being increasingly well documented, specially when associated with the first-choice therapy, which is pharmacotherapy. In this case report, the objective was to investigate the performance of the laser, associated with anticonvulsants, in a patient with trigeminal neuralgia, considering its results from a clinical and thermographic point of view. CASE REPORT: Male patient, 62 years old, presenting idiopathic trigeminal neuralgia, diagnosed 4 years before, being controlled with oxcarbazepine (600mg), divided in 2 daily doses, being the dose doubled in the last year. In the last 4 months, the symptoms worsened with the increase in the drug dosage, generating side effects not supported by the patient. Photobiomodulation was proposed as a complementary treatment, with infrared thermography being performed before and after treatment. After the low-intensity laser therapy protocol, there was a significant improvement, demonstrated both by the patients report and the thermography, maintaining this result in the 6-month control. The dosage was reduced to 300 mg/day, restoring quality of life. CONCLUSION: Low-intensity infrared laser photobiomodulation can be extremely useful when associated with an appropriate drug in the control of idiopathic trigeminal neuralgia, both in the immediate and medium-term outcome.

ABSTRACT Fragile X syndrome (FXS) is a disorder linked to the chromosome X long arm (Xq27.3), which is identified by a constriction named fragile site. It determines various changes, such as behavioral or emotional problems, learning difficulties, and intellectual disabilities. Craniofacial abnormalities such as elongated and narrow face, prominent forehead, broad nose, large and prominent ear pavilions, strabismus, and myopia are frequent characteristics. Regarding the oral aspects, deep and high-arched palate, mandibular prognathism, and malocclusion are also observed. Objective: The purpose of this study was to evaluate the dental radiographic characteristics as described in 40 records of patients with panoramic radiography. Material and Methods: The patients were in the range of 6–17 years old, and were divided into two groups (20 subjects who were compatible with the normality standard and 20 individuals diagnosed with the FXS), which were matched for gender and age. Analysis of the panoramic radiographic examination involved the evaluation of dental mineralization stage, mandibular angle size, and presence of dental anomalies in both deciduous and permanent dentitions. Results: The results of radiographic evaluation demonstrated that the chronology of tooth eruption of all third and second lower molars is anticipated in individuals with FXS (p<0.05). In this group, supernumerary deciduous teeth (2.83%), giroversion of permanent teeth (2.31%), and partial anodontia (1.82%) were the most frequent dental anomalies. In addition, an increase was observed in the mandibular angle size in the FXS group (p<0.05). Conclusion: We conclude that knowledge of dental radiographic changes is of great importance for dental surgeons to plan the treatment of these individuals.